caliber is irrelevant in this discussion ...a 500 S&W mag will shoot through 6 islanders and make a 41mag look like a 32acp. Put a 22mag in an islanders eye or ear hole and I bet he goes down, placement trumps caliber and power probably does too like Gunny states with the lesser caliber 41 vs. bigger the 45acp .....capacity is also a viable factor in all this. 1911's and revolvers are about comparable but high power coupled high capacity leave them in the dust IMO.....
That entire WW2 45 thing don't hold water with me, I mean we are talking about a modern military that was going up against primitive people , and they regular battle rifle was a 30-06 and they needed a pistol with less or same capacity and less power than any rifle on the battlefield to bring these supermen down....how the hell did the Army run out of rifles all of a sudden ?