I haven't had mine long enough to try much variety(although I have stocked up a few)to know what it likes best, but as we all know every barrel has it's peculiar preferences. So far, the only cartridges(30-06) I've put through mine is Winchester 165gr power-point & Remington 180gr core-lokt. I sighted in both the irons at 50yds & the scope at 100yds using the Winchesters. I don't plan on buying any of the high-end ammo for long range precision since I'm not really set up at the farm for those distances, but I would be curious what the Patriot could do at 2-300yds in 30-06. Plus, I just can't see spending $1.50-2.00 a round for shooting paper or the occasional hog. What I have so far to try other than more of the above is Federal power-shok 165gr, Federal non-typical 150gr, & Monarch 150gr. At the maximum distances I'll likely ever use this rifle I'm sure any of the above brands & weights will be fine, but I'm still curious what game load will group best.